Developing nations around the world are realizing the importance of National Project Management Organizations to the development of their vision for economic diversification, better return on investment, job creation, efficiency, auditability and standardized processes and procedures. Analysis of NPMOs around the world indicate a wide range of involvement ranging from an advisory role to a more proactive role. Based on their mandate and authority their effectiveness in the enablement of project delivery varies. The organizational structure, role and responsibility and accrued benefits are analyzed. Recommendations based on lessons learnt are included to drive and inform a better configuration and mandate for NPMOs.